检索范围:
排序: 展示方式:
《医学前沿(英文)》 2021年 第15卷 第6期 页码 903-912 doi: 10.1007/s11684-021-0871-4
关键词: homocysteine hyperhomocysteinemia H-type hypertension Chinese
BASTAMI,Mohammad H. ENTEZARI,Chiwai KWONG,Shizhang QIAO
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 378-385 doi: 10.1007/s11705-014-1441-y
关键词: spinel type polymeric surfactant size evolution mangnetic ferrite nanoparticle
Liver surgery and transplantation in China: Progress and Challenges
LAU W Y, LAI E C H
《医学前沿(英文)》 2007年 第1卷 第1期 页码 1-5 doi: 10.1007/s11684-007-0001-y
关键词: transplantation pyogenic cholangitis available information important hypertension
《医学前沿(英文)》 2023年 第17卷 第1期 页码 156-164 doi: 10.1007/s11684-022-0932-3
关键词: dietary zinc intake new-onset hypertension general population CHNS
Metabolic hypertension: concept and practice
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 201-206 doi: 10.1007/s11684-013-0264-4
Hypertension is a serious public health problem worldwide. More than 60% of the risk factors for hypertension are associated with metabolic disturbances. Metabolic abnormalities increase the risk for hypertension and cause high blood pressure. Improving metabolic disturbances is beneficial for hypertension treatment. Due to the importance of metabolic abnormalities in the pathogenesis of hypertension, we propose a concept of metabolic hypertension. In this review, we discuss and review the clinical types, pathogenesis, risk evaluation and management of metabolic hypertension. Elucidation of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations.
关键词: hypertension cardiometabolic risk factors metabolic abnormalities
Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 395-395 doi: 10.1007/s11684-013-0289-8
A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 367-377 doi: 10.1007/s11684-013-0266-2
This study aimed to modify a chronic ocular hypertension (OHT) rat model to screen for potential compounds to protect retinal ganglion cells (RGCs) from responding to increased intraocular pressure (IOP). A total of 266 rats were prepared and randomly grouped according to different time-points, namely, weeks 3, 8, 16, and 24. Rats were sedated and eye examination was performed to score as the corneal damage on a scale of 1 to 4. The OHT rat model was created via the injection of a hypertonic saline solution into the episcleral veins once weekly for two weeks. OHT was identified when the IOP at week 0 was≥6 mmHg than that at week -2 for the same eye. Viable RGCs were labeled by injecting 4% FluoroGold. Rats were sacrificed, and the eyes were enucleated and fixed. The fixed retinas were dissected to prepare flat whole-mounts. The viable RGCs were visualized and imaged. The IOP (meanβ±βSD) was calculated, and data were analyzed by the paired t-test and one-way ANOVA. The OHT model was created in 234 of 266 rats (87.97%), whereas 32 rats (12.03%) were removed from the study because of the absence of IOP elevation (11.28%) and/or corneal damage scores over 4 (0.75%). IOP was elevated by as much as 81.35% for 24 weeks. The average IOP was (16.68β±β0.98)βmmHg in non-OHT eyes (n = 234), but was (27.95±0.97)βmmHg in OHT eyes (n = 234). Viable RGCs in the OHT eyes were significantly decreased in a time-dependent manner by 29.41%, 38.24%, 55.32%, and 59.30% at weeks 3, 8, 16, and 24, respectively, as compared to viable RGCs in the non-OHT eyes (P<β0.05). The OHT model was successfully created in 88% of the rats. The IOP in the OHT eyes was elevated by approximately 81% for 24 weeks. The number of viable RGCs was decreased by 59% of the rats in a time-dependent manner. The modified OHT model may provide an effective and reliable method for screening drugs to protect RGCs from glaucoma.
关键词: chronic ocular hypertension intraocular pressure retinal ganglion cells neuroprotection glaucoma
Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 67-70 doi: 10.1007/s11684-010-0023-8
关键词: hypertension community pharmacological adherence control of blood pressure
Clinical characteristics of pulmonary hypertension in bronchiectasis
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 336-344 doi: 10.1007/s11684-016-0461-z
Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent PH were included in the study. Patient characteristics at baseline and during follow-up, as well as survival, were analyzed. This observational study was conducted in 36 patients with a mean age of 51.5 years (range, 17?74 years). The 6 min walking distance was 300.8±93.3 m. The mean pulmonary arterial pressure (PAP) was 41.5±11.7 mmHg, cardiac output was 5.2±1.4 L/min, and pulmonary vascular resistance was 561.5±281.5 dyn·s·cm−5. The mean PAP was>35 mmHg in 75% of the cases. Mean PAP was inversely correlated with arterial oxygen saturation values (r = −0.45, P = 0.02). In 24 patients who received oral PAH therapy, systolic PAP was reduced from 82.4±27.0 mmHg to 65.5±20.9 mmHg (P = 0.025) on echocardiography after a median of 6 months of follow-up. The overall probability of survival was 97.1% at 1 year, 83.4% at 3 years, and 64.5% at 5 years. Given the results, we conclude that PH with severe hemodynamic impairment can occur in patients with bilateral bronchiectasis, and PAH therapy might improve hemodynamics in such patients. Prospective clinical trials focusing on this patient population are warranted.
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 322-328 doi: 10.1007/s11684-012-0204-8
The aim of this study was to determine the prevalence of overweight and obese subjects in the Shanghai population of China and its association with undiagnosed hypertension, by taking age, gender and place of residence (urban or suburban) into account. A cross-sectional population-based survey was conducted in 2007. The sample included 13 359 participants aged 15–69 years. Weight, height, and blood pressure were recorded, and information about gender, age and place of residence was obtained. Overweight and obesity prevalence were calculated by the body mass index (BMI) definition recommended by Working Group on Obesity in China (normal weight, 18.5–23.9 kg/m2; overweight, 24–27.9 kg/m2; obesity,≥28 kg/m2). Undiagnosed hypertension was defined by China criteria in accord with that of WHO-ISH (subjects with systolic pressure≥140 mmHg, and/or diastolic pressure≥90 mmHg). Multiple logistic regression analyses were used to assess the association of overweight or obesity with undiagnosed hypertension by adjusting for age, gender and place of residence. The overall overweight, obesity, and undiagnosed hypertension prevalence were 27.6% (95% CI: 26.8–28.4), 6.6% (95% CI: 6.2–7.0), and 15.5% (95% CI: 14.9–16.1), respectively. Compared to normal weight subjects, the odds ratios (OR) for subjects who were overweight and had hypertension was 2.33 (95% CI: 2.10–2.59); that for obesity and hypertension was 4.27 (95% CI: 3.66–4.99). These data suggest that overweight and obesity prevalence and their association with undiagnosed hypertension are high in our study population.
关键词: overweight obesity undiagnosed hypertension prevalence association
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 68-73 doi: 10.1007/s11684-016-0490-7
This study aims to determine whether successful laparoscopic fundoplication for gastroesophageal reflux disease (GERD) can improve the control of hypertension. We conducted an observational study of GERD patients with hypertension. The esophageal and gastroesophageal symptoms of these patients were successfully treated with laparoscopic fundoplication, as measured by the reduced GERD symptoms and proton pump inhibitor consumption. A hypertension control scale was used to classify the use of antihypertensive medications and the quality of blood pressure control before and after anti-reflux surgery. Wilcoxon signed-ranks test was used for the statistical analyses. Seventy GERD patients were included in the analysis and followed up for a mean period of 3.5±1.4 years. Prior to surgery, all participating patients were taking at least one class of antihypertensive medication, and 56 patients (80%) had intermittently high blood pressure. After surgery, the mean number of antihypertensive medication classes per patient was significantly reduced from 1.61±0.77 pre-procedure to 1.27±0.88 post-procedure (P?<?0.001). The blood pressure of 48 of the 56 cases (86%) with preoperative intermittent high blood pressure returned to normal post procedure. A total of 50 patients (71%) recorded improvements on the hypertension control scale, with the overall mean score decreasing from 3.1±1.0 pre-procedure to 1.4±1.0 post-procedure (P?<?0.001). Therefore, successful laparoscopic fundoplication may result in better blood pressure control in some hypertensive GERD patients. This result suggests a possible connection between gastroesophageal reflux and hypertension.
关键词: gastroesophageal reflux disease hypertension blood pressure laparoscopic fundoplication
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
《医学前沿(英文)》 2007年 第1卷 第2期 页码 167-172 doi: 10.1007/s11684-007-0031-5
Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 259-266 doi: 10.1007/s11684-018-0634-z
关键词: lymphangioleiomyomatosis pulmonary hypertension pulmonary function hypoxemia sirolimus
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 29-35 doi: 10.1007/s11684-010-0012-y
关键词: risk factor stroke prothrombin plasminogen activator inhibitor type-1 polymorphism thrombophilia biomarker
《医学前沿(英文)》 2022年 第16卷 第1期 页码 102-110 doi: 10.1007/s11684-021-0850-9
关键词: COVID-19 RAS inhibitor hypertension all-cause mortality
标题 作者 时间 类型 操作
Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018
期刊论文
Influences of spinel type and polymeric surfactants on the size evolution of colloidal magnetic nanocrystals
BASTAMI,Mohammad H. ENTEZARI,Chiwai KWONG,Shizhang QIAO
期刊论文
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study
期刊论文
Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive
null
期刊论文
A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection
null
期刊论文
Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the ShanghaiHypertension Detail Management Program
Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,
期刊论文
Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population
null
期刊论文
Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease
null
期刊论文
Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
期刊论文
Clinical characteristics in lymphangioleiomyomatosis-related pulmonary hypertension: an observation on
Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu
期刊论文
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
期刊论文